Open AccessDownregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer
Author(s) -
Hong-Jian Zhu,
Wenli Zhou,
Yiming Wan,
Ke Ge,
Jun Lü,
Jia Chen
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i8.804
Subject(s) - downregulation and upregulation , liver cancer , orosomucoid , cancer , medicine , cancer research , oncology , biology , gene , glycoprotein , microbiology and biotechnology , biochemistry
Liver cancer has a high mortality and morbidity rate throughout the world. In clinical practice, the prognosis of liver cancer patients is poor, and the complex reasons contribute to treatment failures, including fibrosis, hepatitis viral infection, drug resistance and metastasis. Thus, screening novel prognostic biomarkers is of great importance for guiding liver cancer therapy. Orosomucoid genes ( ORMs ) encode acute phase plasma proteins, including orosomucoid 1 (ORM1) and ORM2. Previous studies showed their upregulation upon inflammation, but the specific function of ORMs has not yet been determined, especially in the development of liver cancer.