Open AccessExtracellular histones stimulate collagen expressionin vitroand promote liver fibrogenesis in a mouse modelviathe TLR4-MyD88 signaling pathway
Author(s) -
Zhi Wang,
Zhaojun Cheng,
Simon T. Abrams,
Ziqi Lin,
Edwin A. Yates,
Qian Yu,
Wenbin Yu,
Pingsheng Chen,
ChengHock Toh,
Guozheng Wang
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i47.7513
Subject(s) - hepatic stellate cell , fibrosis , histone , liver injury , cancer research , hepatic fibrosis , extracellular matrix , biology , tlr4 , signal transduction , chemistry , microbiology and biotechnology , endocrinology , pathology , biochemistry , medicine , gene
Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually. Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood. Recently, the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis. Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.