Open AccessAssociation between ADAMTS13 activity–VWF antigen imbalance and the therapeutic effect of HAIC in patients with hepatocellular carcinoma
Author(s) -
Hiroaki Takaya,
Tadashi Namisaki,
Kyoji Moriya,
Naotaka Shimozato,
Kosuke Kaji,
Hiroyuki Ogawa,
Koji Ishida,
Yosuke Tsuji,
Daisuke Kaya,
H Takagi,
Yukihisa Fujinaga,
Norihisa Nishimura,
Yasuhiko Sawada,
Hideto Kawaratani,
Takemi Akahane,
Masanori Matsumoto,
Hitoshi Yoshiji
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i45.7232
Subject(s) - adamts13 , medicine , von willebrand factor , hepatocellular carcinoma , gastroenterology , angiogenesis , vascular endothelial growth factor , biomarker , predictive marker , oncology , cancer , vegf receptors , platelet , chemistry , biochemistry
Prediction of HAIC treatment response is important for improving the prognosis in patients with hepatocellular carcinoma (HCC). The progression of HCC is related to hypercoagulability and angiogenesis. It is known that ADAMTS13 and von Willebrand factor (VWF) are related to hypercoagulability. In addition, previous study reported that the association between ADAMTS13 and VWF, and angiogenesis via vascular endothelial growth factor (VEGF). Recently, ADAMTS13 and VWF have been associated with the prognosis in patients with various kinds of cancer undergoing chemotherapy.