Open AccessAlteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer
Author(s) -
Xizhen Sun,
Dongyan Zhao,
Yizhuang Zhou,
Qianqian Wang,
Qingshan Geng,
Shukun Yao
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i45.7173
Subject(s) - colorectal cancer , pathogenesis , feces , cancer , gut flora , metabolism , medicine , fecal bacteriotherapy , biology , gastroenterology , cancer research , immunology , microbiology and biotechnology , clostridium difficile , antibiotics
Gut tryptophan (Trp) metabolites are produced by microbiota and/or host metabolism. Some of them have been proven to promote or inhibit colorectal cancer (CRC) in vitro and animal models. We hypothesized that there is an alteration of gut Trp metabolism mediated by microbiota and that it might be involved in the pathogenesis of cancer in patients with CRC.