Open AccessAltered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome
Author(s) -
Wei Wei,
Huifen Wang,
Yu Zhang,
Yanli Zhang,
Bing-Yu Niu,
Shukun Yao
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i45.7153
Subject(s) - irritable bowel syndrome , gastroenterology , gut flora , deoxycholic acid , dysbiosis , medicine , diarrhea , feces , bile acid , chenodeoxycholic acid , microbiome , biology , microbiology and biotechnology , immunology , bioinformatics
Bile acids (BAs) have attracted attention in the research of irritable bowel syndrome with predominant diarrhea (IBS-D) due to their ability to modulate bowel function and their tight connection with the gut microbiota. The composition of the fecal BA pool in IBS-D patients is reportedly different from that in healthy populations. We hypothesized that BAs may participate in the pathogenesis of IBS-D and the altered BA profile may be correlated with the gut microbiome.