Open AccessEffects of Yue-Bi-Tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury
Author(s) -
Jing Hu,
Yumei Zhang,
Yifan Miao,
Lv Zhu,
Xiao-Lin Yi,
Huan Chen,
Xijing Yang,
Mei-Hua Wan,
Wen-Fu Tang
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i43.6810
Subject(s) - acute kidney injury , medicine , acute pancreatitis , kidney , pancreatitis , lung , endocrinology , kidney disease , pathology , gastroenterology
The complications acute lung injury and acute kidney injury caused by severe inflammation are the main reasons of high mortality of severe acute pancreatitis (SAP). These two complications can both lead to water metabolism and acid-base balance disorders, which could act as additional critical factors affecting the disease trend. Aquaporins (AQPs), which can regulate the transmembrane water transport, have been proved to participate in the pathophysiological process of SAP and the associated complications, such as acute lung injury and acute kidney injury. Thus, exploring herbs that can effectively regulate the expression of AQP in SAP could benefit the prognosis of this disease.