Open AccessReactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma
Author(s) -
Yuri Cho,
Min Ji Park,
Koeun Kim,
Sun Woong Kim,
Won-Jin Kim,
SeokYoung Oh,
Joo Ho Lee
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i42.6599
Subject(s) - hippo signaling pathway , cancer research , downregulation and upregulation , signal transduction , small interfering rna , reactive oxygen species , apoptosis , hepatocellular carcinoma , oxidative stress , biology , transfection , cell growth , chemistry , microbiology and biotechnology , cell culture , gene , biochemistry , genetics
The Hippo signaling pathway regulates organ size by regulating cell proliferation and apoptosis with terminal effectors including Yes-associated protein-1 (YAP-1). Dysregulation in Hippo pathway has been proposed as one of the therapeutic targets in hepatocarcinogenesis. The levels of reactive oxygen species (ROS) increase during the progression from early to advanced hepatocellular carcinoma (HCC).