Open AccessP-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration
Author(s) -
Xu Zhang,
Ming Zhu,
Xia Jiang,
Xing Liu,
Lingui Xue,
Pan Liu,
Xianxian Wu,
Zhiwei Yang,
Tao Qin
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i41.6361
Subject(s) - inflammation , immunology , monocyte , medicine , acute pancreatitis , peripheral blood mononuclear cell , endothelial stem cell , biology , biochemistry , in vitro
Acute pancreatitis (AP) is rapid-onset pancreatic inflammation that causes local and systemic inflammatory response syndrome (SIRS) with high morbidity and mortality, but no approved therapies are currently available. P-selectin glycoprotein ligand 1 (PSGL-1) is a transmembrane glycoprotein to initiate inflammatory responses. We hypothesized that PSGL-1 may be involved in the development of AP and would be a new target for the treatment of AP.