Open AccessNew strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism
Author(s) -
Xianwan Jiang,
Yating Li,
Jianzhong Ye,
Longxian Lv,
Liya Yang,
Xiaoyuan Bian,
Wenshuai Wu,
Jingjing Wu,
Ding Shi,
Qing Wang,
Daiqiong Fang,
Kaicen Wang,
Yao Lu,
Jiao-Jiao Xie
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i40.6224
Subject(s) - short chain fatty acid , gut flora , microbiology and biotechnology , fatty acid , metabolism , strain (injury) , chemistry , food science , biochemistry , biology , medicine , fermentation , butyrate
Intestinal dysbiosis has been shown to be associated with the pathogenesis of alcoholic liver disease (ALD), which includes changes in the microbiota composition and bacterial overgrowth, but an effective microbe-based therapy is lacking. Pediococcus pentosaceus ( P. pentosaceus ) CGMCC 7049 is a newly isolated strain of probiotic that has been shown to be resistant to ethanol and bile salts. However, further studies are needed to determine whether P. pentosaceus exerts a protective effect on ALD and to elucidate the potential mechanism.