Open AccessRelationships of early esophageal cancer with human papillomavirus and alcohol metabolism
Author(s) -
Masakí Inoue,
Yuichi Shimizu,
Marin Ishikawa,
Satoshi Abiko,
Yudai Shimoda,
Ikko Tanaka,
Sayoko Kinowaki,
Masayoshi Ono,
Keiko Yamamoto,
Shoko Ono,
Naoya Sakamoto
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i39.6047
Subject(s) - esophageal cancer , human papillomavirus , alcohol , medicine , papillomaviridae , cervical cancer , oncology , biology , cancer , cancer research , biochemistry
It is well known that an alcohol consumption habit together with inactive heterozygous aldehyde dehydrogenase-2 (ALDH2) is an important risk factor for the development of esophageal squamous cell carcinoma (ESCC). It remains controversial whether human papillomavirus (HPV) infection contributes to the occurrence/development of ESCC. There has been no study in which the relationship between ESCC and HPV in addition to alcohol dehydrogenase-1B (ADH1B) and ALDH2 genotypes was evaluated.