Open AccessHerbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn’s disease via signaling involving distinct classes of phosphatidylinositol 3-kinases
Author(s) -
Shiyuan Wang,
Jimeng Zhao,
Cili Zhou,
Handan Zheng,
Yan Huang,
Zhao Min,
Zhiying Zhang,
Luyi Wu,
Huangan Wu,
Huirong Liu
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i39.5997
Subject(s) - autophagy , sequestosome 1 , phosphatidylinositol , pi3k/akt/mtor pathway , kinase , signal transduction , mechanistic target of rapamycin , biology , microbiology and biotechnology , tumor necrosis factor alpha , chemistry , cancer research , biochemistry , immunology , apoptosis
Autophagy is an evolutionarily conserved biological process in eukaryotic cells that involves lysosomal-mediated degradation and recycling of related cellular components. Recent studies have shown that autophagy plays an important role in the pathogenesis of Crohn's disease (CD). Herbal cake-partitioned moxibustion (HM) has been historically practiced to treat CD. However, the mechanism by which HM regulates colonic autophagy in CD remains unclear.