Open AccessIdentification of differentially expressed genes in ulcerative colitis and verification in a colitis mouse model by bioinformatics analyses
Author(s) -
Lei Shi,
Xiao Han,
Junxiang Li,
Yu-Ting Liao,
Fushun Kou,
Zhibin Wang,
Rui Shi,
Xingjie Zhao,
Zijie Sun,
Hao Yu
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i39.5983
Subject(s) - ulcerative colitis , colitis , gene , identification (biology) , biology , bioinformatics , computational biology , medicine , immunology , genetics , disease , botany
Ulcerative colitis (UC) is an inflammatory bowel disease that is difficult to diagnose and treat. To date, the degree of inflammation in patients with UC has mainly been determined by measuring the levels of nonspecific indicators, such as C-reactive protein and the erythrocyte sedimentation rate, but these indicators have an unsatisfactory specificity. In this study, we performed bioinformatics analysis using data from the National Center for Biotechnology Information-Gene Expression Omnibus (NCBI-GEO) databases and verified the selected core genes in a mouse model of dextran sulfate sodium (DSS)-induced colitis.