Open AccessGolgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients
Author(s) -
Nikolaos Gatselis,
Tamás Tornai,
Zakera Shums,
Kalliopi Zachou,
Asterios Saitis,
Stella Gabeta,
Roger Albesa,
Gary L. Norman,
Mária Papp,
George Ν. Dalekos
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i34.5130
Subject(s) - cirrhosis , biomarker , gastroenterology , medicine , disease , liver disease , golgi apparatus , pathology , biology , endoplasmic reticulum , biochemistry
Reliable biomarkers of cirrhosis, hepatocellular carcinoma (HCC), or progression of chronic liver diseases are missing. In this context, Golgi protein-73 (GP73) also called Golgi phosphoprotein-2, was originally defined as a resident Golgi type II transmembrane protein expressed in epithelial cells. As a result, GP73 expression was found primarily in biliary epithelial cells, with only slight detection in hepatocytes. However, in patients with acute or chronic liver diseases and especially in HCC, the expression of GP73 is significantly up-regulated in hepatocytes. So far, few studies have assessed GP73 as a diagnostic or prognostic marker of liver fibrosis and disease progression.