Open AccessImmune and microRNA responses to Helicobacter muridarum infection and indole-3-carbinol during colitis
Author(s) -
Rasha Raheem Alkarkoushi,
Yvonne Hui,
Abbas Tavakoli,
Udai P. Singh,
Prakash Nagarkatti,
Ioulia Chatzistamou,
Marpe Bam,
Traci L. Testerman
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i32.4763
Subject(s) - colitis , immune system , immunology , microrna , helicobacter , medicine , virology , helicobacter pylori , biology , gastroenterology , gene , biochemistry
Indole-3-carbinol (I3C) and other aryl hydrocarbon receptor agonists are known to modulate the immune system and ameliorate various inflammatory and autoimmune diseases in animal models, including colitis induced by dextran sulfate sodium (DSS). MicroRNAs (miRNAs) are also gaining traction as potential therapeutic agents or diagnostic elements. Enterohepatic Helicobacter (EHH) species are associated with an increased risk of inflammatory bowel disease, but little is known about how these species affect the immune system or response to treatment.