Open AccessClinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors
Author(s) -
Huailiang Li,
Linhua Wang,
Yilin Hu,
Ying Feng,
Xiaohong Li,
Yifei Liu,
Peng Li,
Qinghui Mao,
Handong Wang
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i31.4656
Subject(s) - gist , stromal cell , biology , tissue microarray , immunohistochemistry , pathology , surgical oncology , cancer research , oncology , medicine
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Surgical resection and tyrosine kinase inhibitors are defined as the main treatments but cannot cure patients with advanced GIST, which eventually develops into recurrence and acquired drug resistance. Therefore, it is necessary to identify prognostic biomarkers and new therapeutic targets for GISTs. CC chemokine receptor type 8 (CCR8) protein participates in regulation of immune responses. Recent studies on CCR8 in non-small cell lung cancer and colorectal cancer showed that it was highly expressed in tumor-infiltrating regulatory T cells and correlated with a poor prognosis.