Open AccessHepatic microenvironment underlies fibrosis in chronic hepatitis B patients
Author(s) -
Qunyan Yao,
Yadong Feng,
Pei Han,
Feng Yang,
Guangqi Song
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i27.3917
Subject(s) - fibrosis , hepatic fibrosis , medicine , chronic hepatitis , hepatitis b , immunology , gastroenterology , pathology , virus
Chronic hepatitis B virus (HBV) infection is a leading cause of liver morbidity and mortality worldwide. Liver fibrosis resulting from viral infection-associated inflammation and direct liver damage plays an important role in disease management and prognostication. The mechanisms underlying the contribution of the liver microenvironment to fibrosis in HBV patients are not fully understood. There is an absence of effective clinical treatments for liver fibrosis progression; thus, establishing a suitable in vitro microenvironment in order to design novel therapeutics and identify molecular biomarkers to stratify patients is urgently required.