Open AccessNon-invasive prediction of persistent villous atrophy in celiac disease
Author(s) -
Barbora Packová,
Petra Kovalčíková,
Zdeněk Pavlovský,
Daniel Bartušek,
Jitka Prokešová,
Jiří Dolina,
Radek Kroupa
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i26.3780
Subject(s) - villous atrophy , atrophy , medicine , gastroenterology , disease , pathology , coeliac disease
Celiac disease (CD) is an immune-mediated enteropathy that is primarily treated with a gluten-free diet (GFD). Mucosal healing is the main target of the therapy. Currently, duodenal biopsy is the only way to evaluate mucosal healing, and non-invasive markers are challenging. Persistent elevation of anti-tissue transglutaminase antibodies (aTTG) is not an ideal predictor of persistent villous atrophy (VA). Data regarding prediction of atrophy using anti-deamidated gliadin peptide antibodies (aDGP) and abdominal ultrasonography are lacking.