Open AccessAdipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity
Author(s) -
Gao J,
Mosang Yu,
Mengmeng Zhang,
Xue-Wei Gu,
Yue Ren,
Xinxin Zhou,
Dong Chen,
Tang Yan,
Youming Li,
Xi Jin
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i26.3750
Subject(s) - mesenchymal stem cell , wnt signaling pathway , adipose tissue , regeneration (biology) , stem cell , microbiology and biotechnology , biology , cell , colitis , immunity , immunology , immune system , cancer research , signal transduction , endocrinology , biochemistry
Conventional Crohn's disease (CD) treatments are supportive rather than curative and have serious side effects. Adipose-derived mesenchymal stem cells (ADSCs) have been gradually applied to treat various diseases. The therapeutic effect and underlying mechanism of ADSCs on CD are still not clear.