Open AccessTBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma
Author(s) -
Jianfeng Gu,
Wei Fu,
Haixin Qian,
Wenxing Gu,
Yang Zong,
Qian Chen,
Long Lu
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i25.3586
Subject(s) - cancer research , cell growth , cell cycle , apoptosis , pi3k/akt/mtor pathway , biology , protein kinase b , pancreatic cancer , cell , gene knockdown , flow cytometry , cancer , immunology , biochemistry , genetics
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. Identification of diagnostic and therapeutic biomarkers for PDAC is urgently needed. Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) has been linked to the progression of various human cancers. Nevertheless, the function and role of TBL1XR1 in pancreatic cancers are unclear.