Open AccessUse of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine
Author(s) -
Gregorio Di Franco,
Alice Usai,
Niccola Funel,
Matteo Palmeri,
Ida Elena Rosamaria Montesanti,
Matteo Bianchini,
Desirée Gianardi,
Niccolò Furbetta,
Simone Guadagni,
Enrico Vasile,
Alfredo Falcone,
Luca Emanuele Pollina,
Vittoria Raffa,
Luca Morelli
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i21.2792
Subject(s) - xenotransplantation , zebrafish , pancreatic cancer , personalized medicine , medicine , embryo , cancer , bioinformatics , biology , transplantation , genetics , gene
The response to chemotherapy treatment of patients with pancreatic ductal adenocarcinoma (PDAC) is difficult to predict and the identification of patients who most likely will benefit from aggressive chemotherapy approaches is crucial. The concept of personalized medicine has emerged in the last years with the objective to tailor the medical treatment to the individual characteristics of each patient, and particularly to the tumor biology of each patient. The need for in-vivo xenotransplantation models for cancer patients has increased exponentially, and for this reason zebrafish avatars have gained popularity. Preliminary studies were conducted also with PDAC tissue.