Open AccessSleeve gastrectomy ameliorates endothelial function and prevents lung cancer by normalizing endothelin-1 axis in obese and diabetic rats
Author(s) -
Rexiati Ruze,
Yuanyuan Xiong,
Jianwen Li,
Maiying Zhong,
Qian Xu,
Zhibo Yan,
Jiankang Zhu,
Yugang Cheng,
Sanyuan Hu,
Guangyong Zhang
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i20.2599
Subject(s) - medicine , sleeve gastrectomy , lung cancer , endothelin 1 , diabetes mellitus , endothelin receptor , cancer , gastroenterology , endocrinology , surgery , obesity , gastric bypass , weight loss , receptor
Previous evidence has implied that obesity is an independent risk factor for developing cancer. Being closely related to obesity, type 2 diabetes mellitus provides a suitable environment for the formation and metastasis of tumors through multiple pathways. Although bariatric surgeries are effective in preventing and lowering the risk of various types of cancer, the underlying mechanisms of this effect are not clearly elucidated.