Open AccessConservation and variability of hepatitis B core at different chronic hepatitis stages
Author(s) -
Marçal Yll,
María Francesca Cortese,
Mercedes Guerrero-Murillo,
G. Orriols,
Josep Gregori,
Rosario Casillas,
Carolina González,
Sara Sopena,
Cristina Godoy,
Marta Vila,
David Tabernero,
Josep Quer,
Ariadna Rando,
Rosa López-Martínez,
Rafael Estebán,
Mar RiveiroBarciela,
Marı́a Buti
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i20.2584
Subject(s) - virology , medicine , chronic hepatitis , hepatitis , hepatitis b , hepatitis c , immunology , virus
Since it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues to uncover new therapeutic strategies. HBV core protein, encoded by the HBV core gene ( HBC ), intervenes in both structural and functional processes, and is a key protein in the HBV life cycle. For this reason, both the protein and the gene could be valuable targets for new therapeutic and diagnostic strategies. Moreover, alterations in the protein sequence could serve as potential markers of disease progression.