Open AccessImpact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer
Author(s) -
Wenxin Ma,
Peng Xu,
Zhaojun Liu,
Jing Zhou,
Lin Gu,
Jun Zhang,
Dajun Deng
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i2.184
Subject(s) - metastasis , colorectal cancer , cancer , cancer research , medicine , dna methylation , biology , pathology , oncology , gene expression , gene , biochemistry
The expression of the membrane receptor protein GFRA1 is frequently upregulated in many cancers, which can promote cancer development by activating the classic RET-RAS-ERK and RET-RAS-PI3K-AKT pathways. Several therapeutic anti-GFRA1 antibody-drug conjugates are under development. Demethylation (or hypomethylation) of GFRA1 CpG islands (dmGFRA1) is associated with increased gene expression and metastasis risk of gastric cancer. However, it is unknown whether dmGFRA1 affects the metastasis of other cancers, including colon cancer (CC).