Open AccessFolic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα
Author(s) -
FengZhi Xin,
Zhibin Zhao,
Rui-Nan Zhang,
Qin Pan,
Zizhen Gong,
Chao Sun,
JianGao Fan
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i18.2203
Subject(s) - steatohepatitis , folic acid , sirtuin 1 , medicine , nonalcoholic steatohepatitis , steatosis , folic acid supplementation , ursodeoxycholic acid , peroxisome proliferator activated receptor , fatty liver , chemistry , endocrinology , pharmacology , biochemistry , downregulation and upregulation , receptor , disease , nonalcoholic fatty liver disease , gene
Folic acid has been shown to improve non-alcoholic steatohepatitis (NASH), but its roles in hepatic lipid metabolism, hepatic one-carbon metabolism, and gut microbiota are still unknown.