Open AccessSignificance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence
Author(s) -
Mathew George,
Philippe Paci,
Timuçin Taner
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i17.1987
Subject(s) - medicine , liver transplantation , liver fibrosis , fibrosis , pathology , gastroenterology , transplantation
This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation. This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages. Surveillance through protocolized liver allograft biopsy remains the gold standard for diagnosis, and recent evidence suggests that chronic inflammation precedes fibrosis.