Open AccessIron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation
Author(s) -
Élodie Fallet,
Michel Rayar,
Amandine Landrieux,
Christophe Camus,
Pauline HousselDebry,
Caroline Jézéquel,
Ludivine Legros,
Thomas Uguen,
Martine Ropert,
Karim Boudjéma,
Dominique Guyader,
Édouard Bardou-Jacquet
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i16.1938
Subject(s) - liver transplantation , transplantation , medicine , metabolism , listing (finance) , biology , immunology , finance , economics
Liver transplantation (LT) is the best treatment for patients with liver cancer or end stage cirrhosis, but it is still associated with a significant mortality. Therefore identifying factors associated with mortality could help improve patient management. The impact of iron metabolism, which could be a relevant therapeutic target, yield discrepant results in this setting. Previous studies suggest that increased serum ferritin is associated with higher mortality. Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.