Open AccessPTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury
Author(s) -
W Qasim,
Yang Li,
Ruimin Sun,
Decheng Feng,
Zhan-Yu Wang,
Deshun Liu,
Jihong Yao,
Xiaofeng Tian
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i15.1758
Subject(s) - mitochondrial fission , phosphorylation , pten , dnm1l , kinase , microbiology and biotechnology , reperfusion injury , chemistry , mitochondrion , dynamin , apoptosis , cancer research , signal transduction , biology , ischemia , medicine , biochemistry , pi3k/akt/mtor pathway , endocytosis , cell
Intestinal ischemia reperfusion (I/R) occurs in various diseases, such as trauma and intestinal transplantation. Excessive reactive oxygen species (ROS) accumulation and subsequent apoptotic cell death in intestinal epithelia are important causes of I/R injury. PTEN-induced putative kinase 1 (PINK1) and phosphorylation of dynamin-related protein 1 (DRP1) are critical regulators of ROS and apoptosis. However, the correlation of PINK1 and DRP1 and their function in intestinal I/R injury have not been investigated. Thus, examining the PINK1/DRP1 pathway may help to identify a protective strategy and improve the patient prognosis.