Open AccessHereditary gastric cancer: Three rules to reduce missed diagnoses
Author(s) -
Paula Baraúna de Assumpção,
Taíssa Maíra Thomaz Araújo,
André Salim Khayat,
Geraldo Ishak,
Sidney Emanuel Batista dos Santos,
Williams Fernandes Barra,
João Felipe Acioli,
Benedito Mauro Rossi
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i13.1382
Subject(s) - medicine , medical diagnosis , disease , cancer , intensive care medicine , incidence (geometry) , stage (stratigraphy) , mortality rate , pediatrics , pathology , surgery , paleontology , physics , optics , biology
Gastric cancer remains one of the most lethal cancers. The incidence and mortality rates are quite similar. The main reason for the high mortality is diagnosis at advanced stages of disease, when treatment options are poor. One of the supposed strategies to overcome late-stage diagnosis is identifying people at high risk with the aim of establishing rigorous clinical control, including routine endoscopy and biopsies. Hereditary gastric cancer (HGC) syndromes, though representing a sizeable group to monitor for prevention or, at least, for early diagnosis, are apparently extremely rare. The low rate of HGC diagnosis might be related to the low rates of suspicion, insufficient familiarity about clinical diagnosis criteria, and the supposed conditional necessity of a molecular diagnosis. In this review, we will discuss simple measures to increase HGC diagnosis by applying three rules that might provide an opportunity for precision care to benefit the families affected by this disease.