Open AccessSerum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus
Author(s) -
Xi Cao,
Qinghua Shang,
Xiaoling Chi,
Wei Zhang,
Hang Xiao,
Mimi Sun,
Gang Chen,
Yongling An,
Chunlei Lv,
Lin Wang,
Yuemin Nan,
Cuiying Chen,
Zongnan Tan,
Xue-En Liu,
Hui Zhang
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i10.1067
Subject(s) - liver fibrosis , glycan , fibrosis , hepatitis b virus , medicine , virology , hepatitis b , gastroenterology , immunology , virus , pathology , biology , microbiology and biotechnology , glycoprotein
Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection, which may develop into liver fibrosis, cirrhosis and hepatocellular carcinoma. Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion. Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis; however, this method is invasive and prone to clinical sampling error. In order to address these issues, we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.