Open AccessUbiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury
Author(s) -
Anlong Ji,
Tong Li,
Guo Zu,
Decheng Feng,
Yang Li,
Guangzhi Wang,
Jihong Yao,
Xiaofeng Tian
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i7.824
Subject(s) - proliferating cell nuclear antigen , biology , cell cycle , intestinal mucosa , cell growth , reperfusion injury , cyclin d1 , flow cytometry , cyclin b1 , cyclin , cancer research , pathology , immunology , microbiology and biotechnology , cell , immunohistochemistry , ischemia , medicine , biochemistry , cyclin dependent kinase 1
Intestinal ischemia reperfusion (I/R) injury is a serious but common pathophysiological process of many diseases, resulting in a high mortality rate in clinical practice. Ubiquitin-specific protease 22 (USP22) acts as regulator of cell cycle progression, proliferation, and tumor invasion. Depleted USP22 expression has been reported to contribute to arrested cell cycle and disrupted generation of differentiated cell types in crypts and villi. However, the role of USP22 in intestinal damage recovery has not been investigated. Therefore, elucidation of the underlying mechanism of USP22 in intestinal I/R injury may help to improve the tissue repair and patient prognosis in clinical practice.