Open AccessIrisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis
Author(s) -
Yifan Ren,
Meng-Zhou Wang,
Jianbin Bi,
Jia Zhang,
Lin Zhang,
Wu-Ming Liu,
Shasha Wei,
Yi Lv,
Zheng Wu,
Rongqian Wu
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i45.6653
Subject(s) - endocrinology , medicine , oxidative stress , acute pancreatitis , pancreatitis , apoptosis , endoplasmic reticulum , intraperitoneal injection , liver injury , pancreatic injury , arginine , chemistry , biochemistry , amino acid
Acute pancreatitis (AP) is often associated with intestinal injury, which in turn exaggerates the progression of AP. Our recent study has shown that a low level of serum irisin, a novel exercise-induced hormone, is associated with poor outcomes in patients with AP and irisin administration protects against experimental AP. However, the role of irisin in intestinal injury in AP has not been evaluated.