Open AccessKnockdown of lncRNAXLOC_001659 inhibits proliferation and invasion of esophageal squamous cell carcinoma cells
Author(s) -
Fengzhi Li,
Wenqiao Zang
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i42.6299
Subject(s) - gene knockdown , downregulation and upregulation , cell growth , cancer research , biology , gentamicin protection assay , microrna , cell , microarray analysis techniques , cell culture , transfection , microbiology and biotechnology , gene expression , cancer , metastasis , gene , biochemistry , genetics
Studies have shown that long non-coding RNAs (lncRNAs) play a key role in almost all key physiological and pathological processes, including different types of malignant tumors. Our previous lncRNA microarray results have shown that lncRNA XLOC_001659 is upregulated in esophageal cancer (EC) tissues, with a fold change of 20.9 relative to normal esophageal tissues. But its effect and the molecular biological mechanisms on proliferation and invasion of EC cells remain unclear.