Open AccessSustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study
Author(s) -
GianLuca Colussi,
Debora Donnini,
R.F. Brizzi,
S. Maier,
Luca Valenti,
Cristiana Catena,
Alessandro Cavarape,
Leonardo A. Sechi,
Giorgio Soardo
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i40.6094
Subject(s) - medicine , hepatocellular carcinoma , hazard ratio , gastroenterology , interquartile range , hepatitis c , viral load , hepatitis c virus , retrospective cohort study , liver disease , cirrhosis , immunology , confidence interval , virus
Direct-acting antiviral agents (DAAs) are extremely effective in eradicating hepatitis C virus (HCV) in chronically infected patients. However, the protective role of the sustained virologic response (SVR) achieved by second- and third-generation DAAs against the onset of hepatocellular carcinoma (HCC) and mortality is less well established.