Open AccessNucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients
Author(s) -
Xia Zhu,
Kang Chao,
Miao Li,
Wen Xie,
Hong Zheng,
Jinxin Zhang,
P. Hu,
Min Huang,
Xiang Gao,
Xueding Wang
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i38.5850
Subject(s) - thiopurine methyltransferase , leukopenia , nucleoside , nucleotide , genotype , medicine , gastroenterology , crohn's disease , moiety , azathioprine , disease , biology , chemistry , biochemistry , chemotherapy , gene , stereochemistry
Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian population. Although nucleoside diphosphate-linked moiety X-type motif 15 ( NUDT15 ) variants significantly improve the predictive sensitivity of TIL, more than 50% of cases of this toxicity cannot be predicted by this mutation. The potential use of the 6-thioguanine nucleotide (6TGN) level to predict TIL has been explored, but no decisive conclusion has been reached. Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?