Open AccessEvaluation and comparison of short chain fatty acids composition in gut diseases
Author(s) -
Eleiccolai,
Simone Baldi,
Francesca Ricci,
Edda Russo,
Giulia Nannini,
Marta Menicatti,
Giovanni Poli,
Antonio Taddei,
Gianluca Bartolucci,
Antonino Calabrò,
Francesco C. Stingo,
Amedeo Amedei
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i36.5543
Subject(s) - feces , dysbiosis , gut flora , biomarker , medicine , gastroenterology , colorectal cancer , chemistry , food science , biology , cancer , biochemistry , microbiology and biotechnology
An altered (dysbiosis) and unhealthy status of the gut microbiota is usually responsible for a reduction of short chain fatty acids (SCFAs) concentration. SCFAs obtained from the carbohydrate fermentation processes are crucial in maintaining gut homeostasis and their determination in stool samples could provide a faster, reliable and cheaper method to highlight the presence of an intestinal dysbiosis and a biomarker for various gut diseases. We hypothesize that different intestinal diseases, such as celiac disease (CD), adenomatous polyposis (AP) and colorectal cancer (CRC) could display a particular fecal SCFAs' signature.