Open AccessGenomic profile concordance between pancreatic cyst fluid and neoplastic tissue
Author(s) -
A. Laquière,
Arnaud Lagarde,
Bertrand Napoléon,
Raphaël Bourdariat,
Alexandre Atkinson,
Gianfranco Donatelli,
Bernard Pol,
Laurence Lecomte,
Laurence Curel,
Romina Ureña-Campos,
Thierry Helbert,
Vincent Valantin,
François Mithieux,
J. P. Buono,
Philippe Grandval,
Sylviane Olschwang
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i36.5530
Subject(s) - gnas complex locus , kras , concordance , pancreatic cancer , medicine , malignancy , genotype , endoscopic ultrasound , pathology , oncology , biology , cancer , gene , genetics , colorectal cancer , surgery
DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. KRAS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanced neoplasia. Several studies recently demonstrated the ability of next-generation sequencing (NGS) analysis to detect DNA mutations in pancreatic CF, but few studies have performed a systematic comparative analysis between pancreatic CF and neoplastic surgical tissue (NT). The value of CF-NGS analysis indicators for determining surgical resection necessitates evaluation.