Open AccessClostridium butyricumalleviates intestinal low-grade inflammation in TNBS-induced irritable bowel syndrome in mice by regulating functional status of lamina propria dendritic cells
Author(s) -
Qin Zhao,
Wen-Rong Yang,
Xiaohong Wang,
Gaiqin Li,
Leiqi Xu,
Xue Cui,
Yang Liu,
Xiuli Zuo
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i36.5469
Subject(s) - clostridium butyricum , proinflammatory cytokine , lamina propria , immune system , immunology , inflammation , dendritic cell , stromal cell , biology , medicine , pathology , epithelium , genetics , bacteria
Irritable bowel syndrome (IBS) is one of the most common functional gas-troenterological diseases characterized by abnormal visceral sensitivity and low-grade inflammation. The role of Clostridium butyricum ( C. butyricum ) in reducing intestinal low-grade inflammation via immune pathways has been well defined. However, the detailed mechanisms of the effects of C. butyricum on intestinal mucosal immunity, especially on immune cells of the lamina propria, remain unclear. Dendritic cells (DCs), which are important immune cells, secrete proinflammatory cytokines (IL-1β, IL-6, and others) and express T cell immuno-globulin and mucin domain-3 (TIM3), promoting proliferation and activation of DCs, and mediating Th1 and Th17 inflammatory responses.