Open AccessHow doesHelicobacter pyloricause gastric cancer through connexins: An opinion review
Author(s) -
Huan Li,
Canxia Xu,
Rui Gong,
Jingshu Chi,
Peng Liu,
Xiaoming Liu
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i35.5220
Subject(s) - helicobacter pylori , virulence , pathogenicity island , cancer , biology , downregulation and upregulation , carcinogenesis , helicobacter , virulence factor , microbiology and biotechnology , gene , genetics
Helicobacter pylori ( H. pylori ) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis. Investigations into H. pylori infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies. Therefore, in this review, the potential mechanisms of H. pylori -induced gastric cancer through connexins are summarized in detail.