Open AccessAllyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways
Author(s) -
Chunxiao Li,
Gao J,
Xingyong Wan,
Yi Chen,
Chengfu Xu,
Zemin Feng,
Hang Zeng,
Yiming Lin,
Han Ma,
Ping Xu,
Chaohui Yu,
Youming Li
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i34.5120
Subject(s) - allyl isothiocyanate , nonalcoholic fatty liver disease , ampk , sirtuin 1 , amp activated protein kinase , chemistry , inflammation , lipid droplet , lipogenesis , pharmacology , lipid metabolism , sterol regulatory element binding protein , fatty liver , endocrinology , protein kinase a , medicine , downregulation and upregulation , biochemistry , biology , kinase , transcription factor , disease , gene
Allyl isothiocyanate (AITC), a classic anti-inflammatory and antitumorigenic agent, was recently identified as a potential treatment for obesity and insulin resistance. However, little is known about its direct impact on the liver.