Open AccessRegulatory effect of a Chinese herbal medicine formula on non-alcoholic fatty liver disease
Author(s) -
Jing Yang,
Yi-Chih Sun,
Min Wang,
Xinlei Zhang,
Shujing Zhang,
Yue Gao,
Chen Lin,
Mengyao Wu,
Lü Zhou,
Yumei Zhou,
Yue Wang,
Fengjie Zheng,
Yu-Hang Li
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i34.5105
Subject(s) - decoction , fatty liver , medicine , traditional chinese medicine , traditional medicine , gastroenterology , bupleurum , herb , scutellaria , pathology , disease , medicinal herbs , alternative medicine
Non-alcoholic fatty liver disease (NAFLD) has become a major cause of chronic liver disease. The Chinese herbal medicine (CHM) Dachaihu decoction (DCHD) has been proved to treat NAFLD with good efficacy in previous studies. Based on the TCM principle of formula formation, we divided DCHD into soothing liver part, invigorating spleen part, and dredging intestine part. Marshall officially proposed the concept of "intestinal-hepatic axis", which systematically explains the interactions between the intestine and liver. We hypothesized that the effect of CHM on NAFLD is achieved by regulating the liver and intestine. Thus, we aimed to investigate the possible effect of a CHM formula on NAFLD in a rat model.