Open AccessMicroRNA-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2
Author(s) -
Jun-Cheng Wu,
Rong Chen,
Xiaoguang Luo,
Zhenghong Li,
Shengzheng Luo,
Ming-Yi Xu
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i31.4468
Subject(s) - hepatic stellate cell , gene knockdown , ccl4 , hepatic fibrosis , cancer research , microrna , fibrosis , cell growth , biology , akt2 , downregulation and upregulation , microbiology and biotechnology , chemistry , pathology , carbon tetrachloride , medicine , cell culture , endocrinology , signal transduction , akt1 , biochemistry , gene , organic chemistry , pi3k/akt/mtor pathway , genetics
Activation of hepatic stellate cells (HSCs) is a pivotal event in the onset and progression of liver fibrosis. Loss of microRNA-194 (miR-194) has been reported in activated HSCs, but the actual role of miR-194 in liver fibrosis remains uncertain.