Open AccessBioartificial liver support systems for acute liver failure: A systematic review and meta-analysis of the clinical and preclinical literature
Author(s) -
Yuting He,
Yana Qi,
BingQi Zhang,
Jianbo Li,
Ji Bao
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i27.3634
Subject(s) - bioartificial liver device , medicine , meta analysis , randomized controlled trial , cochrane library , adverse effect , clinical trial , relative risk , intensive care medicine , liver transplantation , medline , confidence interval , transplantation , hepatocyte , biochemistry , chemistry , political science , law , in vitro
Acute liver failure (ALF) has a high mortality varying from 80% to 85% with rapid progress in multi-organ system failure. Bioartificial liver (BAL) support systems have the potential to provide temporary support to bridge patients with ALF to liver transplantation or spontaneous recovery. In the past decades, several BAL support systems have been conducted in clinical trials. More recently, concerns have been raised on the renovation of high-quality cell sources and configuration of BAL support systems to provide more benefits to ALF models in preclinical experiments.