Open AccessBotulinum toxin injections after surgery for Hirschsprung disease: Systematic review and meta-analysis
Author(s) -
Daniëlle Roorda,
Zarah Am Abeln,
Jaap Oosterlaan,
L. W. Van Heurn,
Joep P. M. Derikx
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i25.3268
Subject(s) - medicine , botulinum toxin , meta analysis , adverse effect , cochrane library , enterocolitis , surgery , anesthesia , gastroenterology
A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery. Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis, a potential life-threatening condition. Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.