Open AccessProteomics of the mediodorsal thalamic nucleus of rats with stress-induced gastric ulcer
Author(s) -
Shengnan Gong,
Jianping Zhu,
Yuanyuan Ma,
Dongqin Zhao
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i23.2911
Subject(s) - downregulation and upregulation , gsk 3 , gsk3b , western blot , chemistry , biology , pharmacology , medicine , kinase , biochemistry , gene
Stress-induced gastric ulcer (SGU) is one of the most common visceral complications after trauma. Restraint water-immersion stress (RWIS) can cause serious gastrointestinal dysfunction and has been widely used to study the pathogenesis of SGU to identify medications that can cure the disease. The mediodorsal thalamic nucleus (MD) is the centre integrating visceral and physical activity and contributes to SGU induced by RWIS. Hence, the role of the MD during RWIS needs to be studied.