Open AccessAssociation of proton pump inhibitors with risk of hepatic encephalopathy in advanced liver disease: A meta-analysis
Author(s) -
Xinxing Tantai,
Longbao Yang,
Zhongcao Wei,
Cailan Xiao,
Lirong Chen,
Jinhai Wang,
Na Liu
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i21.2683
Subject(s) - medicine , odds ratio , hepatic encephalopathy , meta analysis , cochrane library , subgroup analysis , relative risk , liver disease , cohort study , population , confidence interval , cohort , cirrhosis , environmental health
Several studies have explored the association between the use of proton pump inhibitors (PPIs) and the risk of developing hepatic encephalopathy (HE) in patients with advanced liver disease. However, the evidence-based conclusions are controversial. We hypothesized that using PPIs may increase the risk of HE in patients with advanced liver disease. If confirmed, clinicians must strictly adhere to the indications for PPI treatment in this population.