Open AccessSeven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma
Author(s) -
Xiaohong Xiang,
Li Yang,
Xing Zhang,
Xiaojie Ma,
Runchen Miao,
Jingxian Gu,
Yug Fu,
Qing Yao,
Jingyao Zhang,
Chang Liu,
Ting Lin,
Kai Qu
Publication year - 2019
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v25.i14.1715
Subject(s) - hepatocellular carcinoma , proportional hazards model , gene signature , receiver operating characteristic , senescence , oncology , gene , survival analysis , biology , gene expression profiling , medicine , gene expression , cancer research , genetics
Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma (HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients.