Open AccessClinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis
Author(s) -
Sezin Günaltay,
Lech Rademacher,
Elisabeth Hultgren Hörnquist,
Johan Bohr
Publication year - 2017
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v23.i7.1319
Subject(s) - lamina propria , medicine , gastroenterology , transplantation , colitis , collagenous colitis , microscopic colitis , intraepithelial lymphocyte , refractory (planetary science) , diarrhea , budesonide , immunology , inflammatory bowel disease , pathology , immune system , biology , corticosteroid , disease , epithelium , astrobiology
One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation (FMT) in active collagenous colitis (CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC.