Open AccessSphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer
Author(s) -
Dai Shida,
Satoru Inoue,
Yuki Yoshida,
Atsushi Kodaka,
Tsutomu Tsuji,
Makoto Tsuiji
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i8.2503
Subject(s) - sphingosine kinase 1 , colorectal cancer , lysophosphatidic acid , sphingosine , downregulation and upregulation , cancer , receptor , biology , sphingosine kinase , medicine , real time polymerase chain reaction , kinase , reverse transcription polymerase chain reaction , messenger rna , cancer research , mouse model of colorectal and intestinal cancer , endocrinology , sphingosine 1 phosphate , microbiology and biotechnology , gene , biochemistry
To examine the expression of SphK1, an oncogenic kinase that produces sphingosine 1-phosphate (S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid (LPA) receptor overexpressed in various cancers, in human colorectal cancer.