Open AccessRole of regulatory T cell in the pathogenesis of inflammatory bowel disease
Author(s) -
Akiko Yamada,
Rieko Arakaki,
Masako Saitō,
Tsunematsu Takemoto,
Yasusei Kudo,
Naozumi Ishimaru
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i7.2195
Subject(s) - pathogenesis , inflammatory bowel disease , ulcerative colitis , immunology , disease , immune system , mechanism (biology) , crohn's disease , medicine , regulatory t cell , inflammation , t cell , il 2 receptor , pathology , philosophy , epistemology
Regulatory T (Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of Treg cells. In addition, analyses of patients with IBD facilitate our understanding of the precise mechanism of IBD. This review article focuses on the role of Treg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports.