Open AccessHuman urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway
Author(s) -
Zhigang Ma,
Xiaodan Lv,
Lijun Zhan,
Lan Chen,
Qiyuan Zou,
Ji-Qiao Xiang,
Jiao-Li Qin,
Weiwei Zhang,
Zhaojing Zeng,
Hui Jin,
HaiXing Jiang,
Xiaoping Lv
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i6.2092
Subject(s) - fibrosis , plasminogen activator , hepatic fibrosis , mesenchymal stem cell , ccl4 , sirius red , transplantation , pathology , biology , medicine , endocrinology , chemistry , carbon tetrachloride , organic chemistry
To evaluate the therapeutic effects of bone marrow-derived mesenchymal stem cells (BMSCs) with human urokinase-type plasminogen activator (uPA) on liver fibrosis, and to investigate the mechanism of gene therapy.